tag:blogger.com,1999:blog-12602489.post7670322910698749910..comments2024-03-24T15:07:18.773+01:00Comments on The Stuttering Brain: From Freud to fMRI: Untangling the Mystery of StutteringTom Weidighttp://www.blogger.com/profile/02084153394215001999noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-12602489.post-86235347045871649762011-02-22T11:30:33.810+01:002011-02-22T11:30:33.810+01:00The key issue is that a mutation in one of the thr...The key issue is that a mutation in one of the three genes does not seems to show any noticeable deficiency (except possibly stuttering), but mutations in more than one of the three genes shows significant deficiencies.<br /><br />I suspect the biomolecular pathways in mice are very similar to humans, and so the experiments can look closer at the effect that a single mutation has on the biomolecular "life" of the mouse brain. Either nothing much happens because there is redundancy in the pathways which is only broken at two mutations, or there is some impact. The question is on which regions?Tom Weidighttps://www.blogger.com/profile/02084153394215001999noreply@blogger.comtag:blogger.com,1999:blog-12602489.post-53294599869370853442011-02-21T23:52:06.250+01:002011-02-21T23:52:06.250+01:00Reminds me of the pig who stutters, Porky Pig.
Th...Reminds me of the pig who stutters, Porky Pig.<br /><br />The mouse model and even the pig model have been very useful for many other medical studies. Why not in stuttering research??<br /><br />Beyond mice and pigs, can we think of any other cases of non-human stutterers? How about the people on the estimated 100 million planets with stutterers from Tom's February 4 posting?Orahttps://www.blogger.com/profile/07560420178241698669noreply@blogger.comtag:blogger.com,1999:blog-12602489.post-34266190137427027632011-02-21T23:10:42.048+01:002011-02-21T23:10:42.048+01:00@Olivier:
The mouse is not really about stutterin...@Olivier:<br /><br />The mouse is not really about stuttering, but probably on the impact of the mutations on the mouse's physiology.<br /><br />We know that mutations in more than one of the three genes leads to significant dysfunction, but nothing is known about only one mutation. (as far as I understand)Tom Weidighttps://www.blogger.com/profile/02084153394215001999noreply@blogger.comtag:blogger.com,1999:blog-12602489.post-26102305854510572011-02-21T16:19:22.586+01:002011-02-21T16:19:22.586+01:00why not fish model, it is much cheaper? A stutteri...why not fish model, it is much cheaper? A stuttering mighty mouse named Tom and a stuttering fish called Mark, they fight and disagree.<br /><br />How about inject the stuttering mouse with all kinds of craps and change hormones (give it sex change) because we all know that more males than females stuttter. But why?<br /><br />Stuttering can be related to puberty, and hormones???Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-12602489.post-72110355776194258972011-02-21T14:06:52.204+01:002011-02-21T14:06:52.204+01:00http://www.independent.co.uk/news/science/squeak-d...http://www.independent.co.uk/news/science/squeak-defects-in-mice-could-help-treat-human-stutterers-2220653.html<br /><br />Tom, what is your take on this? Will mouse model work?Misnomernoreply@blogger.comtag:blogger.com,1999:blog-12602489.post-72024193124481020932011-02-21T13:47:56.913+01:002011-02-21T13:47:56.913+01:00Tom, you forgot to mention the world first mouse w...Tom, you forgot to mention the world first mouse who stutters :-)Ohttps://www.blogger.com/profile/13524864055602706537noreply@blogger.com